PI(4,5)P2 Dependent Oligomerization of Fibroblast Growth Factor 2 (FGF2) Triggers the Formation of a Lipidic Membrane Pore Implicated in Unconventional Secretion
نویسندگان
چکیده
Background: PI(4,5)P2 and tyrosine phosphorylation dependent unconventional secretion of FGF2 is mediated by direct translocation across the plasma membrane. Results: PI(4,5)P2 mediated membrane recruitment causes oligomerization of tyrosine phosphorylated FGF2 which, in turn, triggers the formation of a lipidic membrane pore. Conclusion: Membrane inserted FGF2 oligomers represent intermediates of membrane translocation during unconventional secretion. Significance: Mechanistic insight into a novel self sustained mechanism of protein translocation across membranes.
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